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Could Leptin Resistance Be Your Key To Unlocking Midlife Weight Loss?

Do you find yourself struggling to lose weight, despite diet and exercise?

It might be time to look into leptin resistance.

On this episode of The Hormone Prescription, Dr. Bindiya Gandhi joins us to discuss this little-known hormone and how it could be the key to unlocking midlife weight loss. Dr. Gandhi shares her expert insights on leptin resistance, how it develops, and what you can do to overcome it. If you're looking for answers to your weight loss struggles, this is the episode for you!

Dr. Bindiya Gandhi is double board certified physician in Family Medicine and Integrative and Holistic Medicine. She is Atlanta’s Weight Loss doctor and by helping you uncover and tame leptin resistance can turn even the most unsuccessful dieter into a success. She is a media expert and has been featured in The Daily Mail, MindbodyGreen, PopSugar, Clean Plated, Well + Good and more.

She completed her family medicine training from Georgia Regents University/Medical College of Georgia June 2014. She completed her undergraduate training at the University of Georgia with Bachelors of Science in Biology and Psychology in 2004 and her Doctor of Medicine at American University of Antigua College of Medicine in 2010. She completed an Integrative medicine fellowship at the University of Arizona with Dr. Andrew Weil in 2016. She also completed Functional Medicine Training with the Institute of Functional Medicine in 2017.

Her interests include integrative, holistic and functional medicine, women's health, preventative medicine, international medicine and health care reform. Shes also a certified yoga instructor and reiki master. She used to practice emergency medicine as well. Dr. Bindiya is a media expert and contributor to numerous sites including The Daily Mail, MindbodyGreen, PopSugar, Clean Plated, Well + Good and more! When she's not working or writing you can find her in the kitchen cooking, doing yoga or enjoying time with her family & 3 girls

In this episode, you'll learn:

-What leptin resistance is and how it affects weight loss

-How to tell if you're leptin resistant

-Tips for overcoming leptin resistance

-And more!

So tune in and learn how you can finally start losing weight, even if you've been struggling for years.

(00:00): Dr. Bindiya says, If you never try, you will never know and don't underestimate your worth. What does this mean when it comes to your health at midlife? Stay tuned and find out.

(00:14):So the big question is, how do women over 40 like us keep weight off, have great energy, balance our hormones in our moods, feel sexy and confident, and master midlife? If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself Again. As an ob gyn, I had to discover for myself the truth about what creates our rock solid metabolism, lasting weight loss, and supercharged energy after 40, in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results and to give you clarity on the answers to your midlife metabolism challenges. Join me for tangible, natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston. Welcome to The Hormone Prescription Podcast.

(01:07): Hi everybody. Welcome back to another episode of the Hormone Prescription with Dr. Kyrin. Thank you so much for joining me today, we're gonna have fun talking about an aspect of weight loss resistance that you might not have heard of and that has to do with leptin. Don't worry if you don't know what it is. We're gonna dive into it, me and Dr. Binda and let you know so you'll have a full understanding and you'll get some ideas and knowledge and support and inspiration. And after all, that's what we're here for. So she will give you a big dose of that. I'll tell you a little bit about her and we will get started. You're gonna love her because she's not only knowledgeable, she is board certified in family medicine as well as integrative and holistic medicine. She studied with Andrew while who is amazing if you know anything about him.

(02:01): And she completed functional medicine training with the Institute of Functional Medicine in 2017. She's also a media expert and she's been featured in the Daily Mail, Mind Body, green Pop, Sugar, Clean Plated, Well and good and many others. Mostly she's Atlanta's a weight loss doctor, but she works with people remotely all over the country and by she can help you uncover and team and resistance and she can turn even the most unsuccessful dietary into a successful one. And she's here to tell you how and how the missing ingredient is leptin. Welcome, Dr. Binda Gandhi, thank you so much for having me today. Super excited to talk to you about leptin resistance. It's something that we really haven't talked, I don't think at all about on the podcast, and it's super important for women at midlife who are trying to lose weight. So I'm excited to dive into this topic. You know, for me, everything's about hormones and this is one that I have neglected to discuss. So I know a lot of people who are regular listeners are like, Yay, Dr. Karen, finally time, you're talking about leptin resistance. So let's get into it. But I wanna start by having you share with everyone how you honed in on leptin as being the biggest block for women at midlife to lose weight.

(03:21): Oh, you know, such a great question. You know, first of all, leptin is a hormone that is fairly a newer hormone, right? Not many people talk about it. You know, you can go to your endocrinologist and they're not even gonna wanna test this hormone. So just a little background about leptin, you know, it's a hormone that is actually produced by your fat cells and it's important because it communicates with your brain. It's basically our satiety hormone. And this hormone basically tells us if we're full or not. And this hormone is actually impacted by so many other hormones that you probably talk about already, like your thyroid, your estrogen, your progesterone, your insulin. So it's very important to kind of understand what's going on with this homo hormone individually, but how it's also being impacted by the other hormones. So this is why I love talking about it, and I really got into this because when I first started helping patients, a lot of people would come to me because they were struggling to get pregnant and they were having fertility issues. And I started noticing a link between leptin and fertility and then started doing some research and realized, hold up. There's more to the leptin story than just how it impacts fertility. It's also impacting not just our weight, it's impacting so many different aspects of our bodies. And this is why I'm so glad we're talking about this today cuz it's such an important hormone and people need to know about it.

(04:46): It is, and thank you for backing up because some people are like, Le left, what? We've never heard of it. And so we really should start with what is leptin? So thank you for explaining that. It's your satiety hormone and how does it interact with other hormones. So I talk all the time, we talk on the podcast, the Hormone Prescription podcast about what I call the six main metabolic driving hormones, which include your three sex hormones, estrogen, progesterone, testosterone, your thyroid, your cortisol, your insulin, your D H E A. And then there's leftin. And we probably should touch on Grillin too. Yes. Because some people we do touch on melatonin sometimes, but not as being one of the key drivers. But lein is the satiety hormone. Thank you for explaining that. And where does it come from in the body where, how does your body make it? How is it used? How does it work?

(05:41): Mm-Hmm. <affirmative>. Great, great question. So it's produced by our fat cells, right? Essentially. And it communicates with our brain and it basically tells us if we're full or not, right after a meal, we should be getting a message from our brain saying, You've eaten enough, you're full, you don't need to eat anymore. That's essentially what's happening with leptin, right? So it tells us when we're full, where it's sister hormone, I'm gonna bring up grillin is the hunger hormone. This is what stimulates your appetite. And it kind of lets you know if you are hungry, right? So leptin on the other hand, tells you if you're full, grin tells you if you're hungry. Now they work in opposite directions and they work together, but also differently at the same time. Right? When we're hungry, grin is high and we're not satisfied. So lectin is low and the opposite happens when we're full and we're we're satisfied.

(06:35): Grin actually ends up being low and leptin is high. So they work, you know, kind of against each other. Not in a bad way, but like with each other, but like their opposites. So it's really important because Gorlin is actually produced by the stomach of the GI tract, and leptin is produced in the hypothalamus, which is part of the brain. So that's just kind of a little bit about the two hormones and how they work. But it's essential to kind of understand background of it because then you can understand how it works with the other hormones. Kind of like the ones you mentioned, thyroid stress hormones, your cortisol hormones, insulin. So it really does impact so many other things. Leptin is actually metabolized in the liver, right? That's, we know this is where our sex hormones are, are metabolized, right? This is where insulin is metabolized. So this is where our t3, three T3 is metabolized, right? So it's really kind of important how it works with the other hormones and where

(07:34): Great point. So let's dive into that. I know there's some people who are thinking, well, let me see. She said when you're full, your, your leptin goes up. So can I just take some leptin and feel like I'm full all the time? But I gotta ask you that first, cuz I know I'm calling it out. I know my people and I know some people are thinking that right now. So if you can address that, and then let's dive into after that, what are all the things that leap an impact?

(08:01): Yeah, so let's talk, I mean, there are some tips and tricks we can do to kind of keep your body feeling full, right? Like we can definitely talk about, which I'm sure people have mentioned before, have heard before, like for example, drinking water before you eat your dinner or your lunch kind of like starts keeping you full and feeling a little bit more satiated. Eating a lot more fiber, keeps you a lot more satiated, right? So your body feels full there. So there's things that will do that. There is no medication on the market that will keep you full. There are medications on the market that decrease your appetite and there are medications on the market that can improve your leptin and we can talk about that a little bit later. However, there is no prescription FDA anything approved on the market that will directly impact your leptin to make you full earlier, if that makes sense.

(08:50): <Laugh>? Yeah. Okay. All right. So now that we've got that out of the way, you mentioned about leftin being metabolized in the liver and some of the other hormones that are handled by the liver, a lot of them mm-hmm. <Affirmative>. So how does Leftin interact with these other hormones in your body in general?

(09:07): Yeah, so we'll start off with thyroid, cuz I feel like so many women at all ages of life have a thyroid issue, right? Whether it's Hashimotos, just hypothyroidism, hyperthyroidism, whether it's overactive, underactive, unfortunately it is, it is a common problem. So when I look at the thyroid and when I'm, what I'm specifically looking at is I'm actually looking at t3, reverse t3, free t3, total t3, because that gives me a different picture. All right? So I'm gonna get a little technical. So guys, bear with me. Okay? When we talk about our thyroid metabolism, and I'm talking about, I'm looking at your t3 s your T3 free T3 s are impacted by many things. One is stress, okay? Chronic stress, like the pandemic or whatever chronic life changes are happening, right? So chronic stress. And the other thing that is impacting your T3 metabolism is a lot of times if we've been on restrictive diets, okay?

(10:09): So the link between leptin and our T3 metabolism happens When we've been on these restrictive diets for long term, most people, Dr. Karen, have been dieting, especially females have been dieting since their teens, whether they realize it or not. And unfortunately, our culture is all about yo-yo dieting, right? Many of us have tried, including myself, we've all been guilty of different diets to see what works for us, right? So we've been, we've tried slim fast, we've tried the special K diet, and I'm speaking for myself. I've, I'm pretty sure we've tried everything in the book. Right now it's keto, paleo, this, that, like, I don't even know the names of what's been out there, Low fat phase, whatever, right? So because about yoyo dieting, that has messed up our thyroid metabolism. And that's also one of the reasons why we have become leptin resistant, okay?

(11:01): Because of the dysregulation in our metabolism and the dysregulation of our body. So when our body thinks we are starving, when our body thinks that when we have cut calories, essentially, you know, we're trying to do that because the old adage was you have to, you have to starve yourself and you have to over exercise, and that's the only way you're going to lose weight. Well, now we know that's inaccurate, right? Because when we were doing all of those diets and those things, what we were essentially doing is messing up our communication with our brain and our bodies and our, and our fat cells. And this is why we would lose weight initially in the first week. And then we would hit a weight loss stall because the leptin communication started getting dysregulated and disrupting. And that's why we, we couldn't lose weight anymore. That's why diets work short term and then we're like starving and we're like, Oh my God, I need to eat everything in the book. Right? That's a little bit of what's happening right now, The what's happening. Okay,

(12:00): Got

(12:00): It. Because of all the long term havoc on our metabolism, and because we've been kind of, and this diet craze for many, many years, our thyroid metabolism has also changed. And this is why thyroid impacts lectin.