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The

Prescription

Hormone

WITH DR. KYRIN DUNSTON

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Understanding The Key Of YourOral Microbiome For Better Health


We all know that our gut health is important for our overall health, but did you know that our oral microbiome is just as important? In fact, research has shown that there is a strong link between our oral health and our overall health.

For example, studies have shown that people with gum disease are more likely to develop heart disease, stroke, and other chronic illnesses. Therefore, it's important to take care of your oral health in order to maintain your overall health.

David Lin is a leading expert on the oral microbiome, and he's going to be joining us on the show today to talk about how we can maintain our oral health and why it's so important for our overall health.

About David Lin:

David Lin PhD is Co-founder and Chief Scientific Officer at Bristle. David received his PhD in Microbiology and Immunology from the University of Michigan, Ann Arbor, his MS in Biology from California State University, Fullerton, and his BS in Biotechnology from University of California, Davis. He was a postdoctoral researcher at Genentech before becoming a Scientist at Twist Bioscience. He has over 10 years of molecular biology, microbiology, genomics, and synthetic biology, and infectious disease experience across academia, public health, and industry.

In this episode, you'll learn:

  • What the oral microbiome is and why it's so important for our health

  • How to maintain a healthy oral microbiome

  • The link between our oral health and overall health

  • How poor oral health can lead to chronic illnesses

  • And much more!

So tune in now to learn how you can maintain a healthy oral microbiome and improve your overall health!

(00:00): "Worrying is like a rocking chair. It gives you something to do, but it gets you nowhere." - David Lin.

(00:08): So the big question is how do women over 40, like us keep weight off, have great energy balance. Our hormones in our moods feel sexy and confident and master midlife. If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself. Again. As an OB GYN, I had to discover for myself the truth about what creates a rock, solid metabolism, lasting weight loss, and supercharged energy. After 40 in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results. And to give you clarity on the answers to your midlife metabolism challenges, join me for tangible natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston welcome to The Hormone Prescription Podcast.

(01:04): Hi, everybody. Welcome back to another episode of The Hormone Prescription with Dr. Kyrin. Thank you so much for joining me today. My guest today, David Lin PhD is a co-founder and chief scientific officer at Bristol. You might think of Bristol as bristles on your toothbrush. This is a different kind of bristle. Maybe you've heard about the connection between your oral microbiome and your overall systemic health like heart and brain and more. Maybe you haven't, but whether you have, or haven't, you need to know about this. And if you know a little bit about it, you need to know more. So David is gonna share that with you today so that you don't just sit there worrying like a rocking chair about your health and what can you do, but you really get some actionable information, some steps that you can take to improve your health and taking care of your oral microbiome is one of those things that you're not gonna hear about at your dentist that you could be doing to move your health to the next level.

(02:09): So I'll tell you a little bit about David and then we'll get started. David received his PhD in microbiology and immunology from the university of Michigan and armor and his MS in biology from California state university Fullerton, and his bachelor's in biotechnology from university of California Davis. That's a lot of science. He is a science nerd. Let's just say <laugh>. And he loves talking about the oral microbiome. He was a post-doctoral researcher at Gentech before becoming a scientist at twist bioscience and has over 10 years of molecular biology, microbiology, genomics, and synthetic biology and infectious disease experience across academia, public health and industry. This is just the guy you want informing you about how to understand the key of your oral microbiome for better, better health. Welcome David.

(03:08): Thank you. I'm very excited to be here.

(03:10): Yes. I think that most people are not aware of how this small little real estate on their face, their mouth affects the entire rest of their body to such a high degree. So I really wanted to have you on to highlight that for them and they can get some tools and start taking action to improve their oral health so they can improve their overall health. What introduced you to the big impact that oral health has on systemic health?

(03:44): That's a good question. Well, I'm a scientist by training and through many years of school, I've learned to a lot about microbiology, a lot about bacteria and basically the way that they do things and how they interact with your body. And recently, at least in the past decade or two, there's been a lot of research that has shown that the gut microbiome is really important for your overall health. It helps with digestion. It controls a lot of your mood and it does a lot of things, but what's been largely ignored is that there's actually another microbiome. That's the second largest and most diverse microbiome in your body. And it's your mouth. You swallow a hundred billion bacteria every day. You are what you eat and those bacteria are in your mouth. And they do so much for us that we really don't. We don't acknowledge. Did you know that oral bacteria, they actually control some of your blood pressure the way they do this is by reducing nitrate. So there's this circular connection in your mouth where they can reduce nitrate. And that increases the nitrate level, nitric oxide levels in your blood. That's just one of many ways that they help you do things.

(04:49): You know, that's interesting. I know some people, women are listening and saying, oh, maybe when I go for my blood pressure check at my doctor's office, I should ask them to check my oral microbiome. I think the average doctor would just look at you, like, what are you talking about? It would <laugh>. They probably wouldn't know what you're talking about in terms of clinical utility. I know you're affiliated with a company that does testing of the oral microbiome. What percentage of doctors would you say are savvy about this interaction and actually know to order tests like this recommend tests like this work with tests like this?

(05:25): Very, very few. So I think one of the things about medicine is that it's relatively slow moving. There's a lot of tradition that's been built into not only systemic medicine, so, you know, your physician, but also dentistry. Dentistry is a really old practice and they haven't introduced almost any new technologies for like a hundred years. We still operate in the same way we've been doing for a long time. And that is we treat the symptoms as we see them, which is really unfortunate. There's very little preventive measures that we use to really tackle some of the biggest problems we have. I mean, cavities and gum disease, everybody still gets them. It's like, I think 70% of individual over 65 will have periodontal disease and it's entirely preventable. It's just a bacterial infection. That's a very long term bacterial infection. And if you catch it early enough, you don't have to get it.

(06:13): Same with cavities. Cavities are very specific bacteria. They colonize your teeth, they create acid. And unfortunately practitioners nowadays, they, most of them really don't use any of these kinds of tools to screen their patients. I think some of that may have to do with medicine itself, just the way that that we practice. And the other part of it is really that research moves very slowly. So academia to translate a research, finding into something that's really useful for people takes a very long time of development. And hopefully, you know, my company bristle, we're trying to address that at least for oral health.

(06:47): Yes, it's so true. It can take decades. I think that the average is something like three decades and sometimes it's way longer than that, for instance the use of fluoride and toothpaste and water, how does that affect the oral biome?

(07:05): Yeah. So there haven't actually been any very compelling trials regarding the use of at least every day fluoride, which is a very low concentration in your toothpaste, but generally it's not a very powerful antimicrobial. It really doesn't do that much in killing bacteria. But what it really does is to help you remineralize your teeth because fluoride actually helps to reserve calcium onto your tooth surface. So it helps protect your teeth that way. But I think what's more exciting is not just things like fluoride, but there have been newer compounds that have been out where people have shown kind of that they don't have systemic effects like fluoride does, but they can still help re minimalize teeth. So something like nano hydroxy, appetite, even things like arginine. So arginine is, is just an amino acid, but it helps prevent cavities. And, and the way it does it is by actually modulating the oral microbiome. It's a very interesting connection.

(08:05): And is that when swallowed orally Swed orally and how is it administered that it's shown to decrease cavities by altering the microbiome? Yeah,

(08:16): So arginine it just, if you chew it and if it sticks around on your teeth, I'm not actually sure if there have been any tests for ingestion, but if you chew it or if you apply it as a toothpaste, it acts as a prebiotic and it activates this pathway called the arginine D M a pathway, which increases the pH of the mouth and the, the way it modulates the oral microbiome is that there's some bacteria that can metabolize the Aine very well and turn it into ammonia, which increases the pH. And that actually prevents the acid generating bacteria from colonizing the tooth because acid generating bacteria actually really like acidic environments and ammonia is the opposite. So it, it prevents them from growing.

(08:56): Okay. And so what are some everyday habits that people might have that might hurt their oral microbiome and what are some habits they might have that might improve?

(09:07): The first one is using alcohol based mouthwash. That's really bad for you actually. So alcohol is an antiseptic that we use, you know, on our hands. We use it to disinfect things, but it turns out that the microbiome of the mouth, there are very important, good bacteria in there that are important for preventing the bad ones from growing and those good ones. We can kill them by using alcohol based mouthwash. So there was a study recently that had shown that routine use of over the counter mouthwash was actually associated with hypertension. And the reason for that was because these nitrate, reducing bacteria were actually completely going away and they didn't come back because these people were using mouthwash twice a day. And so you never give a chance for good bacteria to populate. And you ended up with dysbiosis of the mouth. That's

(09:54): Fascinating that the regular use of the alcohol containing mouthwash increased hypertension, fascinating. What are some other habits that we have that hurt our oral microbiome?

(10:05): Definitely our diet. This probably isn't unique to just the oral microbiome, but the amount of sugar and processed food that we eat is just off the charts now, compared to where we were even just 20 years ago, even 30 years ago. And so the rates of cavities have gone sky high. And so that's like the main thing that I tell most people it's well, can I fix right now without having to buy anything or actually like change my habits besides diets gotta be diets. Like the diet is the only thing that is entirely controllable and will fix of most of the problem. Stop eating sugar. <Laugh> just the simple sugars are a huge problem.

(10:44): <Laugh> just stop. Just say no,

(10:46): Just

(10:47): Say no. Okay. And how about flossing and brushing? Just gotta say it cuz some people still didn't get the memo.